The developmental process in the field of chemical and biological sciences is continuously undergoing changes in search of further developments in efficiency, productivity, and profitability. Information-guided design strategies and tools could unveil the creativity of a wide range of scientists and engineers by combining expertise from implementation. This book “Modern Approaches in Chemical and Biological Sciences” discusses ways to promote the developing academic paradigm of the chemistry-biology continuum to advance this discovery and developmental process. Through a series of chapters this book tries to identify significant areas and opportunities in chemical biological sciences. The different chapters of this book are contributed by different authors. The articles discuss about ionic liquids as the appropriate replacement for the Volatile Organic Compounds (VOCs) in the industrial and academic sectors as the solvents. The gradual probe desolvation may be another cause for thermosolvatochromism. Determining the structure of small molecule like environment sensitive fluorophoresare is enormously important in bio-chemical and bio-physical research.